Current Research

Rheumatoid Arthritis Patient Reported Outcomes And Certolizumab Pegol Treatment in Vivo Evaluation.

Prof Ernest Choy, Cardiff University.
A prospective, observational study assessing the effectiveness of the anti-TNF medication certolizumab pegol (CZP) in patients with rheumatoid arthritis.

 

A Global Comparative Observational Study in Rheumatoid Arthritis (RA) Patients Who are Treated with a TNF Inhibitor or Tocilizumab as the First Biologic Therapy.

Prof Ernest Choy, Cardiff University.
An observational study that will compare clinical effectiveness and safety outcomes of a TNF inhibitor versus Tocilizumab prescribed to patients starting their first biologic therapy.

 

Using a Smartphone App, Cardiff Arthritis Real-time Evaluator (CARE) to Promote Self Assessment of Disease Activity by Patients with Rheumatoid Arthritis.

Prof Ernest Choy, Cardiff University.
A study that will compare the disease activity of patients who start treatment with traditional and biologic disease modifying drugs using an electronic smartphone application used to self-monitor disease activity.

 

Population-based Ankylosing Spondylitis Study.

Dr Sinead Brophy, Swansea University
The Population-based Ankylosing Spondylitis (PAS) cohort has over 500 participants to date with a diagnosis of AS in Wales. By anonymised data linkage to routine data, patient-derived data is enhanced by routinely collected health-data to characterise the AS patient and explore for early identifiers that can aid detection of the condition.

 

Arthritis Research UK Biomechanics and Bioengineering MRI and MRS assessment with people with and without joint problems.

Prof Vic Duance, Cardiff University 
A longitudinal study that will collect data over the course of the joint disorder or problem using magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS) to examine how patients with arthritis respond to joint loading, perceive pain in the brain and joint in question.

 

Arthritis Research UK Biomechanics and Bioengineering Motion analysis.

Prof Vic Duance, Cardiff University
Assessment of joint function in healthy and pathological subjects using three-dimensional motion analysis techniques. The differences in the motion and loading patterns in the joints of healthy subjects and those who have trauma or pathology affecting their knees, hips, ankles, shoulders, elbow, wrists, hand or spins. The findings will contribute to the development of non-invasive tools to aid orthopaedic consultants and physiotherapists in clinical diagnosis, prognosis of pathologies and assessing functional outcomes.

 

Arthritis Research UK Biomechanics and Bioengineering Fluroscopic imaging of joints.

Prof Vic Duance, Cardiff University
The aim of the study is to enhance current image based motion analysis techniques developed at Cardiff to study the knee and shoulder and to apply these techniques to other joints, where appropriate in order to more accurately quantify the motion of the joint before and after joint surgery, rehabilitation or replacement.

 

Efficacy of oral creatine supplementation in restoring muscle mass and function to rheumatoid arthritis patients.

Prof Andy Lemmey, Bangor University
The aim of the study is to enhance current Oral creatine supplementation is very effective in increasing muscle mass and improving physical function in healthy individuals.  the aim of this investigation is to determine whether similar benefits occur in RA patients.  This study builds on our previous finding (Marcora et al., 2005 Clin Nutr 24:442-54) that protein supplementation elicits significant improvements in muscle mass and function in established RA patients.

 

The prevalence of rheumatoid cachexia in recently diagnosed rheumatoid arthritis patients.

Prof Andy Lemmey, Bangor University
RA patients are characterised by muscle loss (evident in around 67% of patients with controlled disease) and obesity (evident in around 80%). This aberrant body composition phenotype is termed "rheumatoid cachexia", and contributes significantly to increased disability, morbidities and mortality.  The aim of this investigation is to determine whether current more aggressive and effective treatments for RA have reduced the prevalence of rheumatoid cachexia.

 

Efficacy of early, home-based progressive resistance training in improving physical function in elective total hip replacement patients.

Prof Andy Lemmey, Bangor University
The efficacy of an inexpensive home-based exercise program, performed shortly after surgery, in improving body composition and physical function in elective total hip replacement patients was evaluated relative to routine physiotherapy.

 

Cardiovascular fitness in patients with rheumatoid arthritis.

Prof Andy Lemmey, Bangor University
Research has investigated cardio-respiratory fitness, obesity and traditional cardiovascular disease risk factors in patients with rheumatoid arthritis. The research aims to investigate the association between cardio-respiratory fitness and traditional CVD risk factors in RA patients and establish whether exercise can improve these CVD risk factors.

 

Joint health and exercise in rheumatoid arthritis patients.

Dr Rebecca-Jane Law, Bangor University
This research has focused on two areas within this theme. Firstly research on patient and RA health professionals’ perceptions relating to exercise and joint health. Secondly, research has investigated the physiological effects of acute and chronic exercise on novel markers of joint health.

 

Patellofemoral pain syndrome

Dr Kostas Papadopoulous, Bangor University
Our research has focused on developing an evidence-base for assessment, treatment and outcome measurement for patellofemoral pain syndrome, through both qualitative and quantitative methodologies.

 

Please tell us about any research you are conducting in Wales and let us know if you would like to publicise the research here by completing the research studies form.